The Expression of NMDA Receptor 1 Correlates with Clinicopathological Parameters in Cutaneous Squamous Cell Carcinoma
Annals of Dermatology
;
: 382-388, 2009.
Article
in English
| WPRIM
| ID: wpr-174308
ABSTRACT
BACKGROUND:
Ionotropic glutamate receptors of the N-methyl-D-aspartate receptor (NMDAR) type are expressed on keratinocytes and play a role in the proliferation, differentiation, and cornification of keratinocytes. However, the expression profile of NMDAR and its role in cutaneous malignancy is unclear.OBJECTIVE:
We analyzed the expression of NMDAR-1 in cutaneous squamous cell carcinoma (SCC) and investigated the relationship between NMDAR-1 expression and clinicopathological parameters.METHODS:
Thirty-two patients with biopsy-proven cutaneous SCC were enrolled in this study. Each patient was analyzed for tumor diameter, location, local recurrence, and metastasis by conducting a chart review. The SCC specimens were histologically divided into differentiated and undifferentiated groups based on Broders' system. NMDAR-1 expression was examined by performing immunohistochemistry, and the relative staining intensity in the SCCs was graded into 5 levels. According to the staining intensity of NMDAR-1, the specimens were categorized into two groups the higher group and the lower group.RESULTS:
Fifteen (88%) of 17 tumors in the higher group were differentiated SCC, whereas 14 (93%) of 15 tumors in the lower group were undifferentiated SCC. In addition, NMDAR-1 expression was inversely correlated with metastasis (p=0.049). Local recurrence was associated with a lower staining intensity, but the results were not statistically significant.CONCLUSION:
Our results demonstrate that NMDAR-1 expression in cutaneous SCC is significantly correlated with its differentiation and metastasis. Therefore, it may be a prognostic indicator for cutaneous SCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Keratinocytes
/
N-Methylaspartate
/
Receptors, Ionotropic Glutamate
/
Neoplasm Metastasis
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2009
Type:
Article
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