Antiviral Activity of Corylus heterophylla Fisch Against Porcine Epidemic Diarrhea Virus Infection
Journal of Bacteriology and Virology
;
: 159-166, 2016.
Article
in English
| WPRIM
| ID: wpr-174370
ABSTRACT
The porcine epidemic diarrhea virus (PEDV) has recently been shown to cause huge economic losses in the global pork industry. Our results demonstrated that the extract dose-dependently inhibited the replication of PEDV and reduced the visible cytopathic effect (CPE). Treatment with C. heterophylla Fisch extract resulted in marked reduction of PEDVinduced cytokine and chemokine expression. The antiviral activity of C. heterophylla Fisch extract on PEDV replication was found to be primarily exerted at the early stages after infection. Taken together, our data indicate that C. heterophylla Fisch extract may be a good therapeutic agent for use against PEDV and also a potential candidate to be evaluated against other human and animal coronaviruses.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Coronavirus
/
Corylus
/
Porcine epidemic diarrhea virus
/
Red Meat
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Bacteriology and Virology
Year:
2016
Type:
Article
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