Therapeutic Effects of Imipramine and DDAVP in Enuretic Children: A Randomized Prospective Study / 대한비뇨기과학회지
Korean Journal of Urology
;
: 665-671, 2003.
Article
in Korean
| WPRIM
| ID: wpr-174527
ABSTRACT
PURPOSE:
The therapeutic effects of imipramine and DDAVP in primary monosymptomatic enuretic children were compared using a randomized, prospective study. MATERIALS ANDMETHODS:
The study subjects consisted of 23 children, with a mean age of 7.9 years, complaining of monosymptomatic nocturnal enuresis. Baseline evaluations, at the first visit, included voiding diary, enuresis diary, uroflowmetry, urine osmolality, and urine and serum osmolality after a water deprivation test and electrocardiography. After the administration of medication, the changes in the enuretic episodes and adverse effects were evaluated every month.RESULTS:
Sixteen children received medication, and after 2 weeks the drug response rate was 57.1% (4/7) in the imipramine group and 33.3% (3/9) in the DDAVP group. Ten of the 16 children completed the study. After 12 weeks of study, the response rate was 75% (3/4) in the imipramine group and 50% (3/6) in the DDAVP group. There were no significant differences in mean urine osmolalities and functional bladder capacities between the response and no-response groups. During the study, side effects developed in only three of the children in the imipramine group. Of these, one demonstrated tachycardia on a follow-up electrocardiography and another complained of irritability, insomnia, a dry mouth and blurred vision. Subsequently, the two children dropped out due to these side effects.CONCLUSIONS:
The imipramine and DDAVP had similar therapeutic effects, but the DDAVP had fewer side effects, and was better tolerated, than the imipramine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osmolar Concentration
/
Tachycardia
/
Water Deprivation
/
Urinary Bladder
/
Prospective Studies
/
Follow-Up Studies
/
Deamino Arginine Vasopressin
/
Electrocardiography
/
Enuresis
/
Nocturnal Enuresis
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2003
Type:
Article
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