Induction of Apoptosis by alpha1-Adrenoceptor Antagonists in Benign Prostatic Hyperplasia / 대한비뇨기과학회지
Korean Journal of Urology
;
: 643-648, 2003.
Article
in Korean
| WPRIM
| ID: wpr-174531
ABSTRACT
PURPOSE:
Recent evidence has indicated that alpha1-adrenoceptor antagonists induce prostate apoptosis in patients with benign prostatic hyperplasia (BPH). In this study, the effects of different alpha1-adrenoceptor antagonists, on the apoptosis and cell proliferation in the prostatic glandular epithelium and stroma of patients with benign prostatic hyperplasia, were evaluated. MATERIALS ANDMETHODS:
A retrospective analysis was performed on BPH patients for the relief of lower urinary tract symptoms; an untreated (control) group (n=28), and patients treated with terazosin (n=26), doxazosin (n=27) and tamsulosin (n=15) were included. Archival prostate specimens were selected on the basis of availability of previous TURP (transurethral resection of the prostate) specimens. Terazosin, doxazosin and tamsulosin (2-8mg/day) treatment periods ranged from 1 week to 6 years. Ki-67 immunostaining and the TUNEL assay were used to evaluate the proliferative and apoptotic indices for both the epithelial and stromal components of prostate specimens.RESULTS:
A significant induction of apoptosis was observed in patients treated with the alpha1-adrenoceptor antagonists, terazosin and doxazosin, compared with the untreated control group (p0.05).CONCLUSIONS:
Our findings demonstrated that alpha1-adrenoreceptor antagonists may regulate the prostate growth, by inducing apoptosis in both the epithelial and stromal cells, with little effect on the cell proliferation. Apoptosis-mediated prostate stromal regression appears as an additional molecular mechanism underlying the therapeutic response to alpha1-adrenoceptor antagonists in the treatment of BPH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Hyperplasia
/
Retrospective Studies
/
Stromal Cells
/
Doxazosin
/
Apoptosis
/
Adrenergic Antagonists
/
In Situ Nick-End Labeling
/
Transurethral Resection of Prostate
/
Cell Proliferation
Type of study:
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2003
Type:
Article
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