A Polymorphism of the Renin Gene rs6682082 Is Associated with Essential Hypertension Risk and Blood Pressure Levels in Korean Women
Yonsei Medical Journal
;
: 227-234, 2015.
Article
in English
| WPRIM
| ID: wpr-174629
ABSTRACT
PURPOSE:
The aim of the present study was to investigate associations between the renin gene (REN) and the risk of essential hypertension and blood pressure (BP) levels in Koreans. MATERIALS ANDMETHODS:
To outline the functional role of a single nucleotide polymorphism in the transcription of the REN gene, we conducted a case-control study of 1975 individuals 646 hypertension (HT) patients and 1329 ethnically and age-matched normotensive subjects.RESULTS:
Logistic regression analysis indicated that the genotypes AA/AG were strongly associated with risk of HT (odds ratio, 1.493; 95% confidence interval, 1.069-2.086, p=0.018) in female subjects. The genotypes AA/AG also showed significant association with higher blood pressure levels, both systolic and diastolic, in postmenopausal HT women (p=0.003 and p=0.017, respectively). Analysis of the promoter containing rs6682082 revealed a 2.4+/-0.01-fold higher activity in the A variant promoter than the G variant promoter, suggesting that rs6682082 is itself a functional variant.CONCLUSION:
We suggest that the A allele of rs6682082 is a positive genetic marker for predisposition to essential hypertension and high BP in Korean women and may be mediated through the transcriptional activation of REN.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Systole
/
Blood Pressure
/
Transfection
/
Case-Control Studies
/
Risk Factors
/
Promoter Regions, Genetic
/
Renin
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Asian People
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2015
Type:
Article
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