Neutral Sphingomyelinase and Breast Cancer Research
Journal of Menopausal Medicine
;
: 24-27, 2015.
Article
in English
| WPRIM
| ID: wpr-174725
ABSTRACT
Our understanding of the functions of neutral sphingomyelinase (N-SMase) signaling has advanced over the past decade. In this review, we focus on the roles and regulation of N-SMase 1, N-SMase 2, N-SMase 3, an enzyme that generates the bioactive lipid ceramide through the hydrolysis of the membrane lipid sphingomyelin. A large body of work has now implicated N-SMase 2 in a diverse set of cellular functions, physiological processes, and disease pathologies. We focus on different aspects of this enzyme's regulation from transcriptional, post-translational, and biochemical. Furthermore, we expected N-SMase involvement in cellular processes including inflammatory signaling, cell growth, apoptosis, and tumor necrosis factor which in turn play important roles in pathologies such as cancer metastasis, variable disease, and other organ system disorders. Lastly, we examine avenues where targeted N-SMase inhibition may be clinically beneficial in disease scenarios.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Sphingomyelin Phosphodiesterase
/
Breast Neoplasms
/
Tumor Necrosis Factor-alpha
/
Apoptosis
/
Physiological Phenomena
/
Hydrolysis
/
Membranes
/
Neoplasm Metastasis
Language:
English
Journal:
Journal of Menopausal Medicine
Year:
2015
Type:
Article
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