Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling
Experimental & Molecular Medicine
;
: e369-2017.
Article
in English
| WPRIM
| ID: wpr-174863
ABSTRACT
In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased the expression of PU.1 and C/EBPα, which play roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a novel insight into the inhibitory role of SAA in dendritic cell differentiation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dendritic Cells
/
Serum Amyloid A Protein
/
Granulocyte-Macrophage Colony-Stimulating Factor
/
Interleukin-4
/
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
/
Receptors, Formyl Peptide
/
Toll-Like Receptors
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS