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Use of Clozapine for Borderline Personality Disorder: A Case Report
Clinical Psychopharmacology and Neuroscience ; : 226-228, 2016.
Article in English | WPRIM | ID: wpr-175038
ABSTRACT
Patients with borderline personality disorder (BPD) show significant impairment in functioning, particularly in the interpersonal and social domains. Prior reports suggest that clozapine may be effective in the management of BPD. We present the case of a patient with BPD who experienced persistent suicidal ideation and was treated with clozapine at a state psychiatric hospital. After treatment failure with other psychotropic medications, clozapine medication was initiated; not only did suicidal ideation cease, but social and professional functioning also greatly improved to the point of no longer requiring intensive levels of observation or restrictive procedures. Clozapine appears to be efficacious in the management of suicide attempts and self-injurious behavior. Moreover, it appears to be promising as a therapeutic measure for ameliorating the global functioning of patients with severe BPD. Larger, randomized, blinded, and controlled prospective studies are needed to confirm these findings and to determine optimal dosage.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Social Adjustment / Suicide / Borderline Personality Disorder / Prospective Studies / Self-Injurious Behavior / Treatment Failure / Clozapine / Suicidal Ideation / Hospitals, Psychiatric Type of study: Controlled clinical trial / Observational study Limits: Humans Language: English Journal: Clinical Psychopharmacology and Neuroscience Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Social Adjustment / Suicide / Borderline Personality Disorder / Prospective Studies / Self-Injurious Behavior / Treatment Failure / Clozapine / Suicidal Ideation / Hospitals, Psychiatric Type of study: Controlled clinical trial / Observational study Limits: Humans Language: English Journal: Clinical Psychopharmacology and Neuroscience Year: 2016 Type: Article