Aberrant Thalamocortical Synchrony Associated with Behavioral Manifestations in Git1-/- Mice
Experimental Neurobiology
;
: 126-132, 2015.
Article
in English
| WPRIM
| ID: wpr-175045
ABSTRACT
Cross-talk between the thalamus and cortex has been implicated in attention but its pathogenic role in attention-deficit/hyperactivity disorder (ADHD) remains unknown. Here, I demonstrate that Git1-/- mice, previously proposed as an animal model for ADHD, show abnormal theta oscillation in the thalamus. Multi-electrode recordings revealed that Git1-/- mice have hyper-synchrony of neural activities between the thalamus and cortex. The abnormal thalamic oscillation and thalamocortical synchrony in Git1-/- mice were markedly reduced by amphetamine. In addition, ethosuximide ameliorates abnormal thalamic oscillation and ADHD-like hyperactivity shown in Git1-/- mice. My study suggests critical roles of GIT1 and thalamocortical neural circuitry in ADHD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thalamus
/
Models, Animal
/
Ethosuximide
/
Amphetamine
Limits:
Animals
Language:
English
Journal:
Experimental Neurobiology
Year:
2015
Type:
Article
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