In Vitro Activity of Diphenyleneiodonium toward Multidrug-Resistant Helicobacter pylori Strains
Gut and Liver
;
: 648-654, 2017.
Article
in English
| WPRIM
| ID: wpr-175165
ABSTRACT
BACKGROUND/AIMS:
The increased resistance of Helicobacter pylori to antibiotics has increased the need to develop new treatments for this bacterium. The aim of our study was to identify new drugs with anti-H. pylori activity.METHODS:
We screened a small molecule library—the library of pharmacologically active compounds (LOPAC), which includes 1,280 pharmacologically active compounds—to identify inhibitors of H. pylori growth. The minimal inhibitory concentrations (MICs) of antibiotics against multidrug-resistant H. pylori strains were determined using the agar dilution method.RESULTS:
We identified diphenyleneiodonium (DPI) as a novel anti-H. pylori agent. The MIC values for DPI were <0.03 μg/mL against all tested H. pylori strains. DPI also exhibited strong antibacterial activity against common gram-negative and gram-positive pathogenic bacteria.CONCLUSIONS:
DPI may be a candidate anti-H. pylori drug for future development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacteria
/
In Vitro Techniques
/
Helicobacter pylori
/
Helicobacter
/
Drug Resistance, Multiple
/
Agar
/
Methods
/
Anti-Bacterial Agents
Language:
English
Journal:
Gut and Liver
Year:
2017
Type:
Article
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