Carney Complex: Eleven Open Heart Operations in a Single Family
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 471-473, 2017.
Article
in English
| WPRIM
| ID: wpr-175180
ABSTRACT
Herein, we report on a family with Carney complex. Four members of the family underwent a total of 11 open heart operations as well as 9 other operations to treat extrathoracic masses. All the family members met at least 2 major clinical criteria and 1 supplemental criterion. We analyzed their genomic loci, including the protein kinase A regulatory subunit 1 gene. The results revealed no specific mutations, except for a common single nucleotide polymorphism. This case series of Carney complex emphasizes the importance of close longitudinal follow-up because of the high rate of tumor recurrence irrespective of the site. Clinicians should not overlook the specific features of familial myxoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Follow-Up Studies
/
Cyclic AMP-Dependent Protein Kinases
/
Polymorphism, Single Nucleotide
/
Carney Complex
/
Heart
/
Myxoma
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2017
Type:
Article
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