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The Current Status of Multidrug-Resistant Tuberculosis in One Tertiary Hospital in Busan, 2005~2009 / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 120-125, 2011.
Article in Korean | WPRIM | ID: wpr-175247
ABSTRACT

BACKGROUND:

Although the prevalence of pulmonary tuberculosis has progressively decreased all over the world, drug-resistant tuberculosis is major obstacle in treating tuberculosis. This study was performed to examine the current prevalence and risk factors of drug resistant tuberculosis in a single tertiary hospital in Busan, Korea.

METHODS:

We enrolled 367 patients with active pulmonary tuberculosis on a retrospective basis who had undergone mycobacterium culture and drug sensitivity tests between January 2005 and December 2009. We analyzed all clinical and radiographic parameters to find predictors related to drug resistant tuberculosis.

RESULTS:

At least one incident of drug resistance was found in 75 (20.4%) patients. Isoniazid (18.8%) was the most frequent resistant drug, followed by rifampin (10.9%), ethambutol (7.1%), streptomycin (4.9%), and fluoroquinolone (2.7%). Resistance to second-line drugs was found in 37 (10.1%) patients. Multidrug resistance and extensively drug resistance was evident in 39 (10.6%) and 4 (1.1%) patients, respectively. Using multiple logistic regression analysis, history of previous treatment including relapse (odd ratio [OR], 11.3; 95% confidence interval [CI], 4.92~26.08; p<0.01), treatment failure (OR, 24.1; 95% CI, 5.65~102.79; p<0.01) and an age of below 46 years-old (OR, 3.8; 95% CI, 1.62~8.65; p<0.01) were found to be independent predictors of multidrug resistant tuberculosis.

CONCLUSION:

We found that the prevalence of drug resistant tuberculosis was considerably high. A careful consideration for possible drug resistant tuberculosis is warranted in patients with a history of previous treatment or for younger patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Rifampin / Tuberculosis / Tuberculosis, Pulmonary / Drug Resistance / Streptomycin / Logistic Models / Prevalence / Retrospective Studies / Risk Factors Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Humans Language: Korean Journal: Tuberculosis and Respiratory Diseases Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Rifampin / Tuberculosis / Tuberculosis, Pulmonary / Drug Resistance / Streptomycin / Logistic Models / Prevalence / Retrospective Studies / Risk Factors Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Humans Language: Korean Journal: Tuberculosis and Respiratory Diseases Year: 2011 Type: Article