Urinary 6-sulfatoxymelatonin level in girls and its relationship with obesity / 소아과
Korean Journal of Pediatrics
;
: 344-349, 2012.
Article
in English
| WPRIM
| ID: wpr-175379
ABSTRACT
PURPOSE:
Short sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism.METHODS:
A total of 79 girls (6.3 to 12.4 years) were included in this study, of whom 34 were obese; 15, overweight; and 30, normal-weight. We examined their pubertal status and bone age. Fasting serum levels of total ghrelin, leptin, insulin, and first morning urinary 6-OHMS were measured. Homeostatic model assessment-insulin resistance (HOMA-IR) was calculated from the fasting insulin and glucose levels.RESULTS:
There was no significant difference in the creatinine adjusted 6-OHMS levels between the obese girls and the control group. Urinary 6-OHMS did not show any correlations with body mass index (BMI), BMI percentile, total ghrelin, leptin, and HOMA-IR. Negative correlations were found between urinary 6-OHMS levels and chronological and bone ages.CONCLUSION:
Our results suggest that melatonin production is not reduced consistently in obese girls.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Body Weight
/
Body Mass Index
/
Fasting
/
Creatinine
/
Leptin
/
Ghrelin
/
Glucose
/
Insulin
/
Melatonin
/
Obesity
Limits:
Child
/
Humans
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2012
Type:
Article
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