A Study of the Effect of Botulinum Toxin A(Oculinum(R)) in the Case of Abducens Nerve Palsy

ABSTRACT

Seventeen cases of paralytic strabismus secondary to abducens nerve palsy were treated with an injection of Botulinum Toxin A(Oculinum(R)) into the medial rectus muscle under the electromyographic control. All 17 cases, including 3 cases of bilateral abducens palsy, were followed up for 6 months to 23 months after the initial injection, there were no systemic side effects. The etiologic factors follow up deviation angle, dosage and complications were analyzed In the Thirteen cases of Oculinum(R) injection in antagonistic medial rectus muscle, the mean correction of preinjection deviation was 48.7%; the four cases who underwent both Jensen's operation and Oculinum(R) injection obtained 64.6%. The most common complication was ptosis which developed in 15 cases(64.7%) with a dosage of 2.75 u or above. From this study. we concluded that Oculinum(R) chemodenervation was effective in the acute case of abducens palsy without the anterior segment ischemia and systemic side effects.