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Effect of Finasteride on Free/Total Serum PSA Ratio in Patients with Benign Prostate Hyperplasia / 대한비뇨기과학회지
Korean Journal of Urology ; : 1301-1304, 1999.
Article in Korean | WPRIM | ID: wpr-17624
ABSTRACT

PURPOSE:

Finasteride, a 5-alpha reductase inhibitor, has recently been used as a treatment for men with benign prostate hyperplasia(BPH). This study was undertaken to determine whether free-to-total(f/t) PSA ratio changed during the finasteride therapy in patient with BPH and whether it is possible to use this new discriminant ratio after prolonged treatment with finasteride. MATERIALS AND

METHODS:

The study comprised 31 men (mean age 66 years) with finasteride therapy for BPH. Blood samples were taken before and after 3-13months of therapy with finasteride and f/t PSA ratio is determined using radioimmunometric assay.

RESULTS:

Although the mean t-PSA, f-PSA are significantly decreased after the treatment with finasteride, f/t PSA ratio remained unchanged. The duration of treatment and the level of initial t-PSA did not affect the f/t PSA ratio.

CONCLUSIONS:

The f/t PSA ratio is unchanged among the patients with finasteride therapy for BPH.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxidoreductases / Prostate / Prostatic Hyperplasia / Prostatic Neoplasms / Finasteride / Hyperplasia Limits: Humans / Male Language: Korean Journal: Korean Journal of Urology Year: 1999 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxidoreductases / Prostate / Prostatic Hyperplasia / Prostatic Neoplasms / Finasteride / Hyperplasia Limits: Humans / Male Language: Korean Journal: Korean Journal of Urology Year: 1999 Type: Article