Levels of Serum Antioxidant Minerals and Enzyme Capacities of Korean Male Patients with Coronary Artery Disease / 대한지역사회영양학회지

ABSTRACT

Increased oxidative stress contributes to the progression of atherosclerosis. We measured serum antioxidant mineral concentrations, capacities of serum antioxidant enzymes and fasting lipid profile in 97 male patients with coronary artery disease (CAD) and 21 male controls. Nutrient intake was assessed by the semi-quantitative food frequency method. CAD patients were divided into single-vessel disease (SVD, n = 66) and multi-vessel disease (MVD, n = 31) groups on the coronary angiography. The ratio of serum LDL- to HDL-cholesterol elevated with an increasing number of diseased vessels compared to the control (control < SVD Patients with SVD and MVD had higher levels of serum lipoprotein (a) than the control (p < 0.05). The mean intake of carbohydrate, protein and cholesterol was higher in MVD patients and the intakes of vitamins C and E were lower in MVD and SVD patients than in the control (p < 0.05). Serum copper (Cu) and zinc (Zn) levels were higher in MVD and SVD patients than in the control (Cu control 75.8+/-5.07, SVD 99.2+/-2.90, MVD 100.1+/-2.32 microgram/dL, p < 0.01; Zn 76.8+/-5.36, 119.0+/-5.95, 129.1+/-2.70 microgram/dL, p < 0.01). And the ratio of Zn to Cu was higher in SVD and MVD patients than in the control (control 0.78+/-0.06, SVD 0.88+/-0.05, MVD 0.99+/-0.04, p < 0.05). The activity of glutathione peroxidase (GSH-Px) was lower in MVD than in SVD and the control (control 35.13+/-1.34, SVD 35.30+/-1.01, MVD 31.00+/-1.04 U/mg protein, p < 0.05). The ratio of the activities of superoxide dismutase (SOD) to GSH-Px was higher in MVD than in control and SVD (p < 0.05). In groups with CAD, serum Cu and Zn concentrations and their ratio were changed compared to the control. GSH-Px activity was decreased and the ratio of SOD to GSH-Px was increased in the patients with MVD. The balances between the activities of SOD and GSH-Px should also be considered a risk factor in CAD patients.