The effects of inspiratory to expiratory ratio on ventilation and oxygenation during high frequency partial liquid ventilation in a rabbit model of acute lung injury / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 203-209, 2009.
Article
in English
| WPRIM
| ID: wpr-176395
ABSTRACT
BACKGROUND:
We examined the effects of varying inspiratory to expiratory (I E) ratio on gas exchange and hemodynamics during high frequency partial liquid ventilation (HFPLV), a combination of high frequency ventilation (HFV) and partial liquid ventilation (PLV), in a rabbit model of acute lung injury.METHODS:
Twelve rabbits treated with repeated saline lavage were divided into two groups. In the HFPL group (n = 6), 6 ml/kg of perfluorodecaline was administered through the endotracheal tube. Rabbits in this group and in the HFJ group (n = 6) were treated with high frequency jet ventilation (HFJV) at I E ratios of 1 1, 1 2, and 1 3 for 15 minutes, and arterial blood gas, mixed venous blood gas and hemodynamic parameters were measured.RESULTS:
We observed no significant respiratory and hemodynamic differences between the two groups. At an I E ratio of 1 1, the PaO2 was significantly higher, and the shunt rate and PaCO2 were significantly lower in both groups, compared with I E ratios of 1 2 and 1 3. Cardiac output at the 1 3 I E ratio was significantly higher than at 1 1.CONCLUSIONS:
These findings indicate that, in this model, a 1 1 I E ratio was superior for oxygenation and ventilation than I E ratios of 1 2 or 1 3, while having no detrimental effects on hemodynamics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Ventilation
/
High-Frequency Jet Ventilation
/
High-Frequency Ventilation
/
Cardiac Output
/
Liquid Ventilation
/
Acute Lung Injury
/
Hemodynamics
/
Therapeutic Irrigation
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2009
Type:
Article
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