Clinical and epidemiological characteristics of Korean patients with hepatitis C virus genotype 6
Clinical and Molecular Hepatology
;
: 45-50, 2013.
Article
in English
| WPRIM
| ID: wpr-176457
ABSTRACT
BACKGROUND/AIMS:
The distribution of hepatitis C virus (HCV) genotypes varies geographically. In Korea, genotypes 1 and 2 comprise more than 90% of HCV infections, while genotype 6 is very rare. This study compared the clinical and epidemiological characteristics of patients with genotype 6 HCV infection with those infected with HCV genotypes 1 and 2.METHODS:
This was a prospective, multicenter HCV cohort study that enrolled 1,173 adult patients, of which 930 underwent HCV genotype analysis, and only 9 (1.0%) were found to be infected with genotype 6 HCV. The clinical and epidemiological parameters of the genotypes were compared.RESULTS:
The patients with genotype 6 HCV had a mean age of 41.5 years, 77.8% were male, and they had no distinct laboratory features. A sustained virologic response (SVR) was observed in four (67%) of six patients who received antiviral therapy. Risk factors such as the presence of a tattoo (n=6, 66.7%), more than three sexual partners (n=3, 33.3%), and injection drug use (n=3, 33.3%) were more common among genotype 6 patients than among genotypes 1 or 2.CONCLUSIONS:
The epidemiology and treatment response of patients infected with genotype 6 HCV differed significantly from those with genotypes 1 or 2, warranting continuous monitoring.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Sexual Behavior
/
Tattooing
/
RNA, Viral
/
Prospective Studies
/
Risk Factors
/
Cohort Studies
/
Hepacivirus
/
Hepatitis C, Chronic
/
Substance-Related Disorders
Type of study:
Controlled clinical trial
/
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Clinical and Molecular Hepatology
Year:
2013
Type:
Article
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