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Photodynamic Effects of Radachlorin(R) on Cervical Cancer Cells / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 389-394, 2004.
Article in English | WPRIM | ID: wpr-176923
ABSTRACT

PURPOSE:

Photodynamic therapy (PDT) is a novel treatment modality, which produces local tissue necrosis with laser light following the prior administration of a photosensitizing agent. Radachlorin(R) has recently been shown to be a promising PDT sensitizer. In order to elucidate the antitumor effects of PDT using Radachlorin(R) on cervical cancer, growth inhibition studies on a HPV-associated tumor cell line, TC-1 cells in vitro and animals with an established TC-1 tumor in vivo were determined. MATERIALS AND

METHODS:

TC-1 tumor cells were exposed to various concentrations of Radachlorin(R) and PDT, with irradiation of 12.5 or 25 J/cm2 at an irradiance of 20 mW/cm2 using a Won-PDT D662 laser at 662 nm in vitro. C57BL/6 mice with TC-1 tumor were injected with Radachlorin(R) via different routes and treated with PDTin vivo. A growth suppression study was then used to evaluate the effects at various time points after PDT.

RESULTS:

The results showed that irradiation of TC-1 tumor cells in the presence of Radachlorin(R) induced significant cell growth inhibition. Animals with established TC-1 tumors exhibited significantly smaller tumor sizes over time when treated with Radachlorin(R) and irradiation.

CONCLUSION:

PDT after the application of Radachlorin(R) appears to be effective against TC-1 tumors both in vitro and in vivo.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Photochemotherapy / Uterine Cervical Neoplasms / Cell Line, Tumor / Necrosis Limits: Animals Language: English Journal: Cancer Research and Treatment Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Photochemotherapy / Uterine Cervical Neoplasms / Cell Line, Tumor / Necrosis Limits: Animals Language: English Journal: Cancer Research and Treatment Year: 2004 Type: Article