Photodynamic Effects of Radachlorin(R) on Cervical Cancer Cells / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 389-394, 2004.
Article
in English
| WPRIM
| ID: wpr-176923
ABSTRACT
PURPOSE:
Photodynamic therapy (PDT) is a novel treatment modality, which produces local tissue necrosis with laser light following the prior administration of a photosensitizing agent. Radachlorin(R) has recently been shown to be a promising PDT sensitizer. In order to elucidate the antitumor effects of PDT using Radachlorin(R) on cervical cancer, growth inhibition studies on a HPV-associated tumor cell line, TC-1 cells in vitro and animals with an established TC-1 tumor in vivo were determined. MATERIALS ANDMETHODS:
TC-1 tumor cells were exposed to various concentrations of Radachlorin(R) and PDT, with irradiation of 12.5 or 25 J/cm2 at an irradiance of 20 mW/cm2 using a Won-PDT D662 laser at 662 nm in vitro. C57BL/6 mice with TC-1 tumor were injected with Radachlorin(R) via different routes and treated with PDTin vivo. A growth suppression study was then used to evaluate the effects at various time points after PDT.RESULTS:
The results showed that irradiation of TC-1 tumor cells in the presence of Radachlorin(R) induced significant cell growth inhibition. Animals with established TC-1 tumors exhibited significantly smaller tumor sizes over time when treated with Radachlorin(R) and irradiation.CONCLUSION:
PDT after the application of Radachlorin(R) appears to be effective against TC-1 tumors both in vitro and in vivo.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Photochemotherapy
/
Uterine Cervical Neoplasms
/
Cell Line, Tumor
/
Necrosis
Limits:
Animals
Language:
English
Journal:
Cancer Research and Treatment
Year:
2004
Type:
Article
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