Can Prostate-Specific Antigen Kinetics before Prostate Biopsy Predict the Malignant Potential of Prostate Cancer?
Yonsei Medical Journal
;
: 1492-1496, 2015.
Article
in English
| WPRIM
| ID: wpr-177078
ABSTRACT
PURPOSE:
To predict the malignant potential of prostate cancer (PCa) according to prostate-specific antigen velocity (PSAV), PSA density (PSAD), free/total PSA ratio (%fPSA), and digital rectal examination (DRE). MATERIALS ANDMETHODS:
From January 2009 to December 2012, 548 adult male patients were diagnosed with PCa by prostate biopsy at four hospitals in Korea. We retrospectively analyzed 155 adult male patients with an initial PSA level or =8 (n=21)] and the presence of extracapsular invasion [organ confined (n=129) or extracapsular invasion (n=26)]. Differences between the groups were compared.RESULTS:
The group with a Gleason sum > or =8 or extracapsular invasion of PCa showed high PSAV and significantly lower %fPSA. There were no significant differences in PSAD and the presence of an abnormality on DRE between two groups.CONCLUSION:
In PCa patients treated with other therapies besides prostatectomy, a high PSA velocity and a low %fPSA may predict high grade PCa with a Gleason sum > or =8 or the presence of extracapsular invasion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Prostate
/
Prostatectomy
/
Prostatic Neoplasms
/
Biopsy, Needle
/
Kinetics
/
Predictive Value of Tests
/
Retrospective Studies
/
Prostate-Specific Antigen
/
Tumor Burden
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2015
Type:
Article
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