Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea
Gut and Liver
;
: 426-433, 2017.
Article
in English
| WPRIM
| ID: wpr-17720
ABSTRACT
BACKGROUND/AIMS:
The association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea. We aimed to clarify the prevalence of depression and its incidence during PR therapy in chronic hepatitis C (CHC) patients.METHODS:
In this prospective, multicenter study, 114 CHC patients were screened for depression using two self-reported scales, the Beck Depression Inventory-I (BDI-I) and the Hospital Anxiety and Depression scale (HADS). The incidence of depression during PR therapy was evaluated in 62 patients who underwent PR therapy during the study period.RESULTS:
The prevalence of baseline depression was 17.5% according to the BDI-I score ≥10 criterion and 4.4% according to the HADS-D score ≥8 criterion in the 114 CHC patients, and it was significantly associated with an unmarried state. During PR therapy, depression developed in 34.6% according to the BDI-I scale and 29.5% according to the HADS-D, which negatively affected sustained virologic response (SVR).CONCLUSIONS:
The prevalence of depression in Korean CHC patients appears to be low compared to that in Western patients; however, its incidence during PR therapy (approximately 30%) was similar to that of other populations, which led to a lower SVR rate. Active screening and multidisciplinary management of depression during PR therapy is warranted.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Ribavirin
/
Single Person
/
Weights and Measures
/
Mass Screening
/
Incidence
/
Prevalence
/
Prospective Studies
/
Interferons
/
Hepacivirus
Type of study:
Controlled clinical trial
/
Incidence study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Screening study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Gut and Liver
Year:
2017
Type:
Article
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