Predictive Factors for Complete Response and Recurrence after Transarterial Chemoembolization in Hepatocellular Carcinoma
Gut and Liver
;
: 409-416, 2017.
Article
in English
| WPRIM
| ID: wpr-17722
ABSTRACT
BACKGROUND/AIMS:
To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE).METHODS:
Among 691 newly diagnosed HCC patients, 287 were treated with TACE as a first therapy. We analyzed the predictive factors for CR, recurrence after CR, and overall survival (OS).RESULTS:
Eighty-one patients (28.2%) achieved CR after TACE, and recurrence after CR was detected in 35 patients (43.2%). In multivariate analyses, tumor size (≤5 cm) and single nodularity were predictive factors for CR, with hazard ratios (HRs) of 0.35 (p=0.002) and 0.41 (p20 ng/mL) level and multinodularity exhibited significant relationships with recurrence after CR, with HRs of 2.220 (p=0.026) and 3.887 (p5 cm), multinodularity, elevated serum AFP (>20 ng/mL) level, Child-Turcotte-Pugh score (B and C), and portal vein thrombosis were significant factors for OS.CONCLUSIONS:
In patients treated with TACE as a first therapy, tumor size (≤5 cm) and single nodularity were predictive factors for CR, and multinodularity and elevated serum AFP (>20 ng/mL) levels were predictive factors for recurrence after CR. These factors were also significant for OS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Multivariate Analysis
/
Chemoembolization, Therapeutic
/
Carcinoma, Hepatocellular
/
Venous Thrombosis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2017
Type:
Article
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