A Diffusion-based Model Theory of Passive-Targeted Drug Delivery in Solid Tumors / 의학물리
Korean Journal of Medical Physics
;
: 161-166, 2007.
Article
in English
| WPRIM
| ID: wpr-177491
ABSTRACT
A model theory of passive-targeted drug delivery in sphere-shaped solid tumors is introduced on the basis of Fick's law of diffusion, with appropriate boundary and initial conditions. For a uniform initial concentration inside the tumor, the concentration is obtained as a function of time and radial position. The concentration is shown to approach the equilibrium distribution as the time elapses, as is expected by the Gedanken Experiment. The time-evolution rate is found to be determined by the diffusion coefficient of the drug in the tissue, the size of the tumor, the volume of the drug-injected region, and the concentration gradient at the boundary.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Diffusion
/
Jurisprudence
Type of study:
Prognostic study
Language:
English
Journal:
Korean Journal of Medical Physics
Year:
2007
Type:
Article
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