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Open-Label Observational Study for Evaluating the Short-term Benefits of Rabeprazole Medication on Laryngopharyngeal Reflux
Clinical and Experimental Otorhinolaryngology ; : 28-33, 2012.
Article in English | WPRIM | ID: wpr-17754
ABSTRACT

OBJECTIVES:

The aims of this study were to determine the benefits of short-term empirical proton pump inhibitor (PPI) medication on laryngopharyngeal reflux (LPR) and to determine whether scores on the reflux symptom index (RSI) and the reflux finding score (RFS) could be combined to identify subgroups of patients that will more likely to improve with this medication.

METHODS:

Fifty-one Korean Otolaryngology Board-certified specialists joined this prospective, multi-center, and open-label observational study. A total of 1,142 adult patients with LPR was enrolled for 12 weeks of rabeprazol medication. According to pre-treatment scores on RSI and RFS, patients were divided into 4 subgroups. RFS and RSI were measured repeatedly with a month interval along the treatment period. Changes of RSI and RFS were analyzed in an overall study cohort as well as in each subgroup.

RESULTS:

Approximately 40% (n=455) of enrolled patients were followed up until 12 weeks of PPI treatment. Significant improvement in RSI was obtained in 29%, 58%, and 75% of patients after 4, 8, and 12 weeks of PPI medication. RFS was improved in 16%, 42%, and 57% of the patients with 4, 8, and 12 weeks of PPI medication. All subgroups showed improvement regardless of their pre-treatment scores on the RSI and RFS.

CONCLUSION:

Even though RSI and RFS may be used as a general guideline for LPR management, pre-treatment RSI and RFS are not useful in predicting the patients' response to short-term PPI medication in the usual pattern of practice for LPR, which is mostly based on the physical evaluation and history taking.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Otolaryngology / Specialization / Prospective Studies / Cohort Studies / Proton Pumps / 2-Pyridinylmethylsulfinylbenzimidazoles / Proton Pump Inhibitors / Laryngopharyngeal Reflux Type of study: Controlled clinical trial / Etiology study / Practice guideline / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Humans Language: English Journal: Clinical and Experimental Otorhinolaryngology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Otolaryngology / Specialization / Prospective Studies / Cohort Studies / Proton Pumps / 2-Pyridinylmethylsulfinylbenzimidazoles / Proton Pump Inhibitors / Laryngopharyngeal Reflux Type of study: Controlled clinical trial / Etiology study / Practice guideline / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Humans Language: English Journal: Clinical and Experimental Otorhinolaryngology Year: 2012 Type: Article