Clinical Studies on the Hypotensive Effect of Non-Thiazide Diuretics, Sulfamoyl Benzamide

ABSTRACT

Thizide diuretics which are widely used nowadays, are considered to be drugs of first choice of antihypertensive agents, due to their slow and useful diuretic effects in hypertensive patients. But their adverse effects have been noted as hypokalemia and hyperuricemia. A newly developed non-thiazide diuretic agent, Sulfamoyl benzamide has been known as slow effective and safe diuretics as thiazides through several previous studies. And all the studies showed no serious hypokalemia or hyperuricemia. Authors administrated Sulfamoyl benzamide to 20 patients of essential hypertension for 4 weeks, who visited the Department of Internal Medicine of han Yang University Hospital from Nov.82' to May 83', and observed its hypotensive effect and its adverse effect as follows. 1) Before Sufamoyl benzamide administeration, mean arterial systolic pressure and mean arterial diastolic pressure of 20 patients of essential hypertension were 165.5+/-7.23 mmHg and 99.8+/-4.93 mmHg, respectively. The Mean Arterial Pressure(MAP) was 121.7+/-4.48 mmHg. After 4 weeks of treatment, the mean arterial systolic pressure, mean arterial diastolic pressure, and MAP were decreased to 148.3+/-10.64 mmHg(p<0.01), 94.3+/-6.40 mmHg(p<0.01), and 112.1+/-6.66 mmHg(p<0.01), respectively. 2) After 4 weeks of treatment, the hypotensive effect on each of 20 hypotensive patients was evaluated using our arbitrary scoring system which is decided by the degree of reduction of arterial systolic pressure and diastolic pressure. In all patients, useful hypotensive effect was noted. Out of 20 patients, 11 patients(55%) were 'Mild effective', 6 patients(30%) were 'Moderate effective', and 3 patients(15%) were 'Mild effective'. By MAP, the meaningful hypotensive effect was observed in 12 patients(60%), and there were a 'Mild effect' in 6 of 12 patients, a 'Moderate effect' in 4 of 12 patients, and a 'Marked effect' in 2 of 12 patients. 3) There was no adverse side effect except mild dizziness in only 1 patient, which was improved spontaneously after reduction of dosage of Sulfamoyl benzamide from 30 mg to 15mg whitout any specific treatment.