Evaluation of the safety of non-thermal atmospheric-pressure plasma in hairless mouse tissues / 대한구강보건학회지
Journal of Korean Academy of Oral Health
;
: 148-153, 2014.
Article
in Korean
| WPRIM
| ID: wpr-177670
ABSTRACT
OBJECTIVES:
The aim of the present study was to evaluate the stability of non-thermal atmospheric-pressure plasma on Candida albicans in hairless mouse-2 (HRM-2) tissues.METHODS:
HRM-2 mice were subjected to non-thermal atmospheric-pressure plasma jet treatment using an optical fiber probe and monitored using a thermometer. The skin of HRM-2 mice was treated with plasma jet for 0, 60, 180, and 300 s per day for 5 days. After plasma treatment, morphological changes in Candida albicans on the skin of these mice were examined using a scanning electron microscope. Biopsy of the plasma-treated skin was performed and the tissues were histologically analyzed using hematoxylin and eosin (H&E) and Masson's trichrome stains.RESULTS:
The scanning electron microscopic images revealed the morphological changes in the membrane structure of the plasma-treated Candida albicans. Histological analysis showed that non-thermal plasma treatment did not cause epidermal damage or tissue inflammation and did not significantly modify the collagen layers of the mouse skin.CONCLUSIONS:
The results of this study suggest that non-thermal atmospheric-pressure plasma might be safe and effective for clinical applications in the field of dentistry.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Skin
/
Thermometers
/
Biopsy
/
Candida albicans
/
Microscopy, Electron, Scanning
/
Collagen
/
Eosine Yellowish-(YS)
/
Dentistry
/
Coloring Agents
Limits:
Animals
Language:
Korean
Journal:
Journal of Korean Academy of Oral Health
Year:
2014
Type:
Article
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