Effect of Adiponectin and Resistin on Coronary Plaque Composition and Coronary Artery Remodeling of Target Lesion in Patients with Stable Angina
Journal of Lipid and Atherosclerosis
;
: 69-78, 2012.
Article
in Korean
| WPRIM
| ID: wpr-178012
ABSTRACT
OBJECTIVE:
The purpose of this study was to investigate the effect of adiponectin and resistin on coronary plaque composition determined by virtual histology (VH) intravascular ultrasound (IVUS) and coronary artery remodeling of target lesion in patients with stable angina.METHODS:
We prospectively enrolled 48 patients who underwent coronary angiography and VH IVUS for stable angina (27 men, 61+/-9 years of age). Preintervention grayscale and VH IVUS analysis was done across the target lesion. Planar VH IVUS analysis at the minimum luminal site and volumetric analysis over a 10-mm-long segment centered at the minimum luminal site were performed. The subjects were divided into 2 groups based on remodeling index (RI) positive remodeling (PR) defined as RI>1.0 and non-PR as RI< or =1.0. Blood samples for analysis of adiponectin and resistin were obtained from the femoral artery before coronary angioplasty.RESULTS:
Of the 48 patients enrolled, 23 (48%) had PR in their target lesion and 25 (52%) were non-PR group. Clinical and angiographic characteristics, VH IVUS parameters were not different between the PR and the non-PR groups. Adiponectin and resistin levels showed no significant correlations with coronary plaque composition evaluated with VH IVUS. Adiponectin showed no significant difference between the two groups. However, resistin showed trend toward higher level in non-PR group (4.17+/-2.18 ng/mL vs. 6.11+/-4.26 ng/mL, P=0.056) and a significant negative correlation with RI (r=-0.303, P=0.036).CONCLUSION:
We found a negative correlation between the resistin level and RI of a de-novo target lesion in patients with stable angina.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenobarbital
/
Prospective Studies
/
Coronary Angiography
/
Coronary Vessels
/
Adiponectin
/
Resistin
/
Femoral Artery
/
Plaque, Atherosclerotic
/
Angina, Stable
Type of study:
Observational study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Journal of Lipid and Atherosclerosis
Year:
2012
Type:
Article
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