Your browser doesn't support javascript.
loading
Predictors of Intravesical Recurrence After Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma: An Inflammation-Based Prognostic Score
Korean Journal of Urology ; : 453-459, 2014.
Article in English | WPRIM | ID: wpr-178076
ABSTRACT

PURPOSE:

Systemic inflammatory responses, which are defined in terms of the Glasgow prognostic score (GPS), have been reported to be independent predictors of unfavorable outcomes in various human cancers. We assessed the utility of the GPS as a predictor of intravesical recurrence after radical nephroureterectomy (RNU) in upper urinary tract carcinoma (UTUC). MATERIALS AND

METHODS:

We collected data for 147 UTUC patients with no previous history of bladder cancer who underwent RNU from 2004 to 2012. Associations between perioperative clinicopathological variables and intravesical recurrence were analyzed by using univariate and multivariate Cox regression models.

RESULTS:

Overall, 71 of 147 patients (48%) developed intravesical recurrence, including 21 patients (30%) diagnosed with synchronous bladder tumor. In the univariate analysis, performance status, diabetes mellitus (DM), serum albumin, C-reactive protein, GPS, and synchronous bladder tumor were associated with intravesical recurrence. In the multivariate analysis, performance status (hazard ratio [HR], 2.33; 95% confidence interval [CI], 1.41-3.85; p=0.001), DM (HR, 2.04; 95% CI, 1.21-3.41; p=0.007), cortical thinning (HR, 2.01; 95% CI, 1.08-3.71; p=0.026), and GPS (score of 1 HR, 6.86; 95% CI, 3.69-12.7; p=0.001; score of 2 HR, 5.96; 95% CI, 3.10-11.4; p=0.001) were independent predictors of intravesical recurrence.

CONCLUSIONS:

Our results suggest that the GPS as well as performance status, DM, and cortical thinning are associated with intravesical recurrence after RNU. Thus, more careful follow-up, coupled with postoperative intravesical therapy to avoid bladder recurrence, should be considered in these patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Ureter / Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / Survival Analysis / Retrospective Studies / Risk Factors / Urologic Neoplasms / Systemic Inflammatory Response Syndrome / Neoplasm Grading Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Korean Journal of Urology Year: 2014 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Ureter / Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / Survival Analysis / Retrospective Studies / Risk Factors / Urologic Neoplasms / Systemic Inflammatory Response Syndrome / Neoplasm Grading Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Korean Journal of Urology Year: 2014 Type: Article