Refractory rickets caused by mild distal renal tubular acidosis
Annals of Pediatric Endocrinology & Metabolism
;
: 152-155, 2013.
Article
in English
| WPRIM
| ID: wpr-178351
ABSTRACT
Type I (distal) renal tubular acidosis (RTA) is a disorder associated with the failure to excrete hydrogen ions from the distal renal tubule. It is characterized by hyperchloremic metabolic acidosis, an abnormal increase in urine pH, reduced urinary excretion of ammonium and bicarbonate ions, and mild deterioration in renal function. Hypercalciuria is common in distal RTA because of bone resorption, which increases as a buffer against metabolic acidosis. This can result in intractable rickets. We describe a case of distal RTA with nephrocalcinosis during follow-up of rickets in a patient who presented with clinical manifestations of short stature, failure to thrive, recurrent vomiting, dehydration, and irritability.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protons
/
Rickets
/
Acidosis
/
Acidosis, Renal Tubular
/
Vomiting
/
Bicarbonates
/
Bone Resorption
/
Follow-Up Studies
/
Dehydration
/
Hypercalciuria
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2013
Type:
Article
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