Vitamin B12 Deficiency after a Total Gastrectomy in Patients with Gastric Cancer
Journal of the Korean Gastric Cancer Association
;
: 6-10, 2006.
Article
in Korean
| WPRIM
| ID: wpr-178390
ABSTRACT
PURPOSE:
The most common metabolic defect appearing following a gastrectomy is anemia. Two types have been identified One is related to a deficiency in iron and the other is related to an impairment in vitamin B12 metabolism. The purpose of this study is to evaluate the incidence and treatment of vitamin B12 deficiency after a total gastrectomy. MATERIALS ANDMETHODS:
Serum vitamin B12 concentrations were measured in 128 patients who had undergone a total gastrectomy. The group with a serum concentration under 200 pg/ml was supplemented at one-month intervals with Actinamide and five-six months later, serum concentrations of the vitamin B12 were rechecked.RESULTS:
The group with vitamin B12 under 200 pg/ml was 61 (47.6%) of the 128 patients who had undergone a total gastrectomy. In this group, the cumulative incidences of vitamin B12 deficiency were 7.0, 23.4, 33.6, 39.1, 41.4, and 47.7% at 6 months, 1, 2, 3, 4, and 5 or more years, respectively. The treated group with vitamin B12 under 200 pg/ml had 36 (28.17%) of the 128 patients. The 16 of those cases with vitamin B12 levels of 100~150 pg/ml were supplemented 5.21 times and the vitamine B12 was elevated to above 650 pg/ml. The other 20 cases with an average of vitamin B12 levels of 150~200 pg/ml were supplemented an average of 4.75 times, and the vitamin B12 was elevated to above 780 pg/ml.CONCLUSION:
It is necessary to supplement vitamin B12 even 1 year later after a total gastrectomy. The group with vitamin B12 under 200 pg/ml was supplemented 5~6 times at one-month intervals with Actinamide 1,000microgram IM injections and reached normal levels.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
Vitamin B 12
/
Vitamins
/
Vitamin B 12 Deficiency
/
Incidence
/
Gastrectomy
/
Anemia
/
Iron
/
Metabolism
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Gastric Cancer Association
Year:
2006
Type:
Article
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