HRCT Findings of Bleomycin-Related Lung Toxicity: A Report of 2 Case
Journal of the Korean Radiological Society
;
: 83-86, 1997.
Article
in English
| WPRIM
| ID: wpr-17851
ABSTRACT
Many drugs can result in a variety of pathologic reactions in the lung, especially the cytotoxic drugs. Amongcytotoxic drugs bleomycin is a prototype. Bleomycin-related pulmonary toxicity is usually known as dose-dependent and can be enhanced with concurrent oxygen therapy, irradiation, or other chemotherapeutic agents. The incidence of bleomycin-induced pulmonary toxicity has been reported as varying from 2 to 46%, and 1% of fatal lung disease. We describe the radiographic and HRCT findings of bleomycin-related pulmonary toxicity developed in two patients one in ovarian teratocarcinoma, the other malignant lymphoma patient. Chest radiographs and HRCT of these patients showed ground-glass opacities, consolidation, linear and reticular opacities, and interlobular septal thickening. These abnormalities were bilateral, and symmetrical and were found predominantly in the area of mid-and lower-lung zone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Bleomycin
/
Radiography, Thoracic
/
Incidence
/
Teratocarcinoma
/
Lung
/
Lung Diseases
/
Lymphoma
Type of study:
Diagnostic study
/
Incidence study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of the Korean Radiological Society
Year:
1997
Type:
Article
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