Molecular Epidemiology of Hepatitis A Virus in the South-East Area of Gyeonggi-do in Korea
Yonsei Medical Journal
;
: 512-516, 2009.
Article
in English
| WPRIM
| ID: wpr-178613
ABSTRACT
PURPOSE:
Hepatitis A virus (HAV) has been a leading cause of acute hepatitis in Korea. The reported genotypes of acute hepatitis A in Korea are the subgenotype IA and IB. The aim of the present study is to investigate HAV genotypes in the south-east area of Gyeonggi-do in Korea. MATERIALS ANDMETHODS:
From June 2004 to June 2006, 46 acute hepatitis A patients were enrolled prospectively. All had sporadic acute hepatitis A patients. All suspected cases of acute hepatitis A were tested for IgM anti-HAV antibodies. We sequenced 168 bp of nucleotides of the putative VP1/P2A junction and determined the HAV genotype with reverse transcriptase polymerase chain reaction. The clinical and laboratory results of all patients were recorded.RESULTS:
HAV-ribonucleic acid (RNA) was detected in 41 samples out of 46 samples. Among the 41 samples, 25 (60%) were shown to have subgenotype IIIA and the other 16 (40%) were subgenotype IA. Several amino acid substitutions were found.CONCLUSION:
In these HAV sporadic cases, IIIA and IA were identified, and this may reflect co-circulation of various genotypes in Korea. This study provides valuable new data on the genetic distribution of HAV and important information to help design appropriate public health measures.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Hepatitis A Virus, Human
/
Molecular Epidemiology
/
Reverse Transcriptase Polymerase Chain Reaction
/
Genotype
/
Hepatitis A
/
Korea
Type of study:
Screening study
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2009
Type:
Article
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