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Molecular Epidemiology of Hepatitis A Virus in the South-East Area of Gyeonggi-do in Korea
Yonsei Medical Journal ; : 512-516, 2009.
Article in English | WPRIM | ID: wpr-178613
ABSTRACT

PURPOSE:

Hepatitis A virus (HAV) has been a leading cause of acute hepatitis in Korea. The reported genotypes of acute hepatitis A in Korea are the subgenotype IA and IB. The aim of the present study is to investigate HAV genotypes in the south-east area of Gyeonggi-do in Korea. MATERIALS AND

METHODS:

From June 2004 to June 2006, 46 acute hepatitis A patients were enrolled prospectively. All had sporadic acute hepatitis A patients. All suspected cases of acute hepatitis A were tested for IgM anti-HAV antibodies. We sequenced 168 bp of nucleotides of the putative VP1/P2A junction and determined the HAV genotype with reverse transcriptase polymerase chain reaction. The clinical and laboratory results of all patients were recorded.

RESULTS:

HAV-ribonucleic acid (RNA) was detected in 41 samples out of 46 samples. Among the 41 samples, 25 (60%) were shown to have subgenotype IIIA and the other 16 (40%) were subgenotype IA. Several amino acid substitutions were found.

CONCLUSION:

In these HAV sporadic cases, IIIA and IA were identified, and this may reflect co-circulation of various genotypes in Korea. This study provides valuable new data on the genetic distribution of HAV and important information to help design appropriate public health measures.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phylogeny / Hepatitis A Virus, Human / Molecular Epidemiology / Reverse Transcriptase Polymerase Chain Reaction / Genotype / Hepatitis A / Korea Type of study: Screening study Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Yonsei Medical Journal Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phylogeny / Hepatitis A Virus, Human / Molecular Epidemiology / Reverse Transcriptase Polymerase Chain Reaction / Genotype / Hepatitis A / Korea Type of study: Screening study Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Yonsei Medical Journal Year: 2009 Type: Article