Microvessel Density and Expressions of bcl-2, p53, and Vascular Endothelial Growth Factor in Endometrial Carcinoma
Korean Journal of Pathology
;
: 401-407, 2001.
Article
in Korean
| WPRIM
| ID: wpr-178665
ABSTRACT
BACKGROUND:
Recent studies have shown that oncogenes and tumor suppressor genes are involved in tumorigenesis and tumor progression. The inverse role of bcl-2 and p53 in endometrial carcinomas has been debated. Moreover, their roles in angiogenesis as well as the interrelationship between prognostic clinico-pathological factors and angiogenesis have not been elucidated in endometrial carcinomas.METHODS:
The expression rates of bcl-2, p53 and vascular endothelial growth factor (VEGF) in thirty-eight cases of surgically removed endometrial carcinomas were investigated using an avidin-biotin complex method of immunohistochemistry. CD34 immunostain for microvessel density (MVD) was also performed.RESULTS:
The expression rate of bcl-2 was higher in the endometrioid type carcinoma (43.8%) than in the non-endometriod type carcinoma (16.7%). There was a significantly increased bcl-2 expression in grade I compared to grades II and III (P<0.05). The p53 expression rate was significantly higher in the non-endometriod type carcinoma than in the endometrioid type carcinoma (P<0.05).The VEGF expression rate was higher in the non-endometriod type carcinoma (83.3%) than in the endometrioid carcinoma (28.1%). Differences of MVD according to stages, histological types, grades and bcl-2, p53 and VEGF expressions were not noted.CONCLUSIONS:
The expression rate of bcl-2 increases in the low grade endometrial carcinoma more than in the high grade one, so it may be suggested that bcl-2 expression could be used for an ancillary prognosticator. However, p53 and VEGF expressions and microvessel density may not have any prognostic value.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Immunohistochemistry
/
Genes, Tumor Suppressor
/
Endometrial Neoplasms
/
Carcinoma, Endometrioid
/
Vascular Endothelial Growth Factor A
/
Endometrium
/
Microvessels
/
Carcinogenesis
Type of study:
Prognostic study
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
2001
Type:
Article
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