beta-Catenin Expression in Gastric Carcinogenesis
Korean Journal of Pathology
;
: 376-382, 2001.
Article
in Korean
| WPRIM
| ID: wpr-178668
ABSTRACT
BACKGROUND:
The molecular pathogenesis of gastric carcinoma is not yet well characterized. The purpose of this study is to assess the role of beta-catenin in gastric carcinogenesis.METHODS:
We analyzed beta-catenin expression using immunohistochemistry on 68 gastric adenomas and 34 gastric adenocarcinomas, and compared the result with pathological and molecular types of tumors and E-cadherin expression.RESULTS:
Nuclear expression of beta-catenin was noted more frequently in gastric adenomas than in carcinomas (40% vs. 21%, 0.05< or = P<1). There was no significant relationship between nuclear beta-catenin expression and histologic degree of adenoma, histologic type of carcinoma or microsatellite instability. E-cadherin expression showed significantly more frequent decrease in the membrane stainability of carcinomas compared to adenomas (P<0.01).CONCLUSIONS:
The frequent nuclear beta-catenin expression in gastric adenomas suggests that the beta-catenin alteration might play an early role in gastric carcinogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
Immunohistochemistry
/
Adenocarcinoma
/
Adenoma
/
Cadherins
/
Microsatellite Repeats
/
Beta Catenin
/
Microsatellite Instability
/
Carcinogenesis
/
Membranes
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
2001
Type:
Article
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