The Effect of Cyclosporin A on Delayed Adjustable Strabismus Surgery in Rabbits

ABSTRACT

The delayed adjustable strabismus surgery may be desirable because the angle of strabismus can be changed after the strabismus surgery. We have studied the effect of 2% cyclosporin A on the delayed adjustable strabismus surgery in rabbits. Two percent cyclosporin A was soaked for 5 minutes for group 4 and 10 minutes for group 5 between the conjunctiva and sclera during the adjustable strabismus surgery on the eyes of New Zealand white rabbits. The eyes in group 1 received only adjustable strabismus surgery, and those in group 2 and 3 received the surgery including 5 minutes and 10 minutes soaking with castor oil, respectively. We evaluated the time of adjustability and measured the traction force and length during adjustment after the adjustable strabismus surgery. We could adjust in all of the 6 eyes in group 4 and 5 two weeks after the surgery. At 1 week, the traction forces were 30.7+/-14.0 (mean+/-SD), 42.0+/-39.6, 31.7+/-7.5, 24.0+/-7.5, and 21.8+/-6.0 gm in group 1, 2, 3, 4, and 5, respectively. The forces in group 4 and 5 were not significantly different from those in group 1, 2, and 3. At 2 weeks, the degrees of adhesion between the conjunctiva and superior rectus muscle, and those between the muscle and sclera were significantly lower in group 4 and 5 than those in group 1, 2, and 3. These results suggest that 2% cyclosporin A soaking is useful to obtain the better results due to the delayed adjustment by decreasing the adhesion around the muscle (J KoreanOphthalmol Soc 412115~2123, 2000).