Eradication Rates of First-line and Second-line Therapy for Helicobacter pylori Infection in Gyeongnam Province
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
;
: 160-165, 2015.
Article
in Korean
| WPRIM
| ID: wpr-179131
ABSTRACT
BACKGROUND/AIMS:
The eradication rates of Helicobacter pylori has been decreasing over the years and it is different among the regions. The aim of this study was to investigate the rates of first-line and the second-line eradication of H. pylori over the last 5 years in a single institute of Changwon and Gyeongsangnam-do, Korea. MATERIALS ANDMETHODS:
Eradication rates of first-line triple regimen in 1,164 patients and second-line quadruple regimen in 223 patients who received H. pylori eradication treatment from January 2008 to December 2012 at Changwon Fatima Hospital were evaluated retrospectively. The patients for second-line quadruple therapy were divided into three groups according to the dosage of medications.RESULTS:
The overall eradication rates of first-line and second-line therapy were 70.5% and 81.2%, respectively. There was no decreasing tendency in the eradication rate of first-line therapy for 5 years (P=0.573). However, annul eradication rates of second-line therapy significantly decreased (P=0.001, linear by linear association). In second-line therapy, patients treated with high dose bismuth and metronidazole had higher eradication rates than those treated with low dose bismuth and metronidazole (P=0.039).CONCLUSIONS:
The effectiveness of the first-line and second-line therapy for H. pylori was suboptimal. In addition, there was a decreasing tendency in the eradication rates of second-line therapy over the past 5 years in Changwon and Gyeongsangnam-do province. Alternative regimens or high dose therapy should be considered for first-line and second-line therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bismuth
/
Retrospective Studies
/
Helicobacter pylori
/
Helicobacter
/
Korea
/
Metronidazole
Type of study:
Observational study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
Year:
2015
Type:
Article
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