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Evaluation of Usefulness of Radio-iodine SPECT/CT in Differentiated Thyroid Cancer / 핵의학분자영상
Nuclear Medicine and Molecular Imaging ; : 350-358, 2007.
Article in Korean | WPRIM | ID: wpr-179423
ABSTRACT

PURPOSE:

Localizing and differentiating a metastatic lesion of differentiated thyroid cancer (DTC) by using radio?iodine whole body scan could be difficult because a whole body scan (WBS) lacks anatomic information. This study was performed to evaluate the usefulness of radio-iodine SPECT/CT for differentiating equivocal lesions. MATERIALS AND

METHODS:

Among 253 patients with DTC who had undergone radio-iodine scan between February and July 2006, 26 patients were enrolled (MF = 818, Age 50.7 +/- 12.5 years) in this study. The patients had abnormal uptakes in the WBSs that necessitated precise anatomical localization for differentiating between a metastatic lesion and a false-positive lesion. SPECT/CT was performed for the region with abnormal uptake in the WBS. WBS and SPECT/CT were evaluated visually. Metastases were diagnosed based on the results of the radio-iodine scan along with the results of other radiological examinations and serological tests.

RESULTS:

Based on the WBS images, 13 were suspected with cervical lymph node (LN) metastases in 16 patients with abnormal neck uptake, and in the 11 patients with abnormal extra-cervical uptakes, extra-cervical metastases were doubtful in all. After SPECT/CT was performed, the diagnostic results were altered for 16 patients (62%). SPECT/CT revealed that only 5 patients had cervical LN metastases, while 3 patients had extra-cervical (mediastinal) LN metastases. Overall, there was a 58% (15/26) change in diagnoses and plans for treatment due to SPECT/CT. Among 8 patients suspected with metastases on SPECT/CT, 6 patients underwent another radio-iodine therapy. In 96% (24/25) of the patients, the results of SPECT/CT corresponded with those of further radiological examinations and with other clinical information.

CONCLUSION:

Radio-iodine SPECT/CT images permitted the differentiation of abnormal radio-iodine uptake and improved anatomical interpretation in DTC.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Thyroid Gland / Serologic Tests / Thyroid Neoplasms / Diagnosis / Whole Body Imaging / Lymph Nodes / Neck / Neoplasm Metastasis Type of study: Diagnostic study Limits: Humans Language: Korean Journal: Nuclear Medicine and Molecular Imaging Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Thyroid Gland / Serologic Tests / Thyroid Neoplasms / Diagnosis / Whole Body Imaging / Lymph Nodes / Neck / Neoplasm Metastasis Type of study: Diagnostic study Limits: Humans Language: Korean Journal: Nuclear Medicine and Molecular Imaging Year: 2007 Type: Article