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A Case of Spontaneous Pregnancy in Patient with Premature Ovarian Failure Who Has a Y Chromosome / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 144-147, 2003.
Article in Korean | WPRIM | ID: wpr-179648
ABSTRACT
Premature ovarian failure is a condition causing amenorrhea, hypoestrogenism, and elevated gonadotropins in women younger than 40 years. A karyotype should be performed as part of basic laboratory evaluation for all patients with premature ovarian failure and prodromal premature ovarian failure. Gonadal dysgenesis represents a wide spectrum of clinical phenotypes, gonadal structures that include the presence of at least one streak gonad, and a variety of X chromosome abnormalities and mosaicism. Development of a malignancy in a dysgenetic gonad is of major concern. The presence of a fragment of the Y chromosome is thought to be a key to the oncogenic potential of these gonads. Malignant potential is clearly not linked to the testicular determining factor itself (SRY). Failure to display SRY or a closely related sequence does not rule out the presence of the segment of the Y chromosome postulated to be associated with the development of malignancies. Pregnancy in premature ovarian failure with chromosomal abnormality is rare. Furthermore, the incidence of pregnancy in patient with Y chromosome is very rare. We have experienced a case of premature ovarian failure with chromosomal abnormality involving Y chromosome fragment. She has got pregnant spontaneously and gave birth to male baby but he was found to have the same karyotype as his mother. So we report this case with a brief review of literatures.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / X Chromosome / Y Chromosome / Incidence / Chromosome Aberrations / Primary Ovarian Insufficiency / Parturition / Karyotype / Amenorrhea / Gonadal Dysgenesis Type of study: Incidence study / Prognostic study Limits: Female / Humans / Male / Pregnancy Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / X Chromosome / Y Chromosome / Incidence / Chromosome Aberrations / Primary Ovarian Insufficiency / Parturition / Karyotype / Amenorrhea / Gonadal Dysgenesis Type of study: Incidence study / Prognostic study Limits: Female / Humans / Male / Pregnancy Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 2003 Type: Article