Chromosomal gains and losses in primary ovarian carcinomas by comparative genomic hybridization / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 38-43, 2003.
Article
in Korean
| WPRIM
| ID: wpr-179663
ABSTRACT
OBJECTIVE:
Comparative genomic hybridization was performed to evaluate DNA sequence copy number changes in human ovarian carcinomas from paraffin-embedded tissue blocks. PATIENTS ANDMETHODS:
DNA from 20 cases of primary ovarian carcinomas underwent comparative genomic hybridization to evaluate the extent of genetic gains or losses in a test sample.RESULTS:
In thirteen cases of 20 samples, varying degree of genetic imbalances was observed. Of the remaining 7 cases, two revealed normal, five failed to yield a result. Most common genetic imbalances are 8q22.2-q24 site amplification and 12p site amplification, where c-myc gene and k-ras gene respectively are included. Second most common site of genetic imbalance is 7p21-pter site deletion.CONCLUSION:
Our results have shown many chromosomal alterations in human ovarian carcinomas, and these sites are known previously as oncogene or tumor-suppression gene, and some sites are not known specific cancer associated sites. Our data can be useful for screening chromosomal changes and molecular mechanism of human ovarian carcinogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Ovarian Neoplasms
/
DNA
/
Base Sequence
/
Mass Screening
/
Genes, myc
/
Genes, ras
/
Comparative Genomic Hybridization
/
Carcinogenesis
Type of study:
Screening study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2003
Type:
Article
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