A Case of Cyclosporine A: Induced Encephalopathy in a Child with Nephrotic Syndrome / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 342-346, 2000.
Article
in Korean
| WPRIM
| ID: wpr-179735
ABSTRACT
Cyclosporine A is the most frequently used immunosuppressive agent for prevention of graft versus host disease (GVHD) and treatment of frequently relapsing nephrotic syndrome in childhood. Some adverse effects such as hepatic and renal toxicity, have been frequently encountered. But central nervous system toxicity caused by cyclosporine A is rare, and the incidence of encephalopathy among patients recieving cyclosporine A is unknown. Brain magnetic resonance imaging is an essential tool for diagnosis of cyclosporine A neurotoxicity. It typically demonstrates nonenhancing symmetric subcortical, and sometimes deep white matter changes resembling edema with posterior hemisphere predominance. We report a child with nephrotic syndrome who developed encephalopathy during cyclosporine A therapy. Based on this study, we emphasize that careful follow up of patient's neurological finding is very important to prevent serious life-threatening complications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Magnetic Resonance Imaging
/
Central Nervous System
/
Incidence
/
Follow-Up Studies
/
Cyclosporine
/
Diagnosis
/
Edema
/
Graft vs Host Disease
/
Nephrotic Syndrome
Type of study:
Diagnostic study
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
Korean
Journal:
Journal of the Korean Child Neurology Society
Year:
2000
Type:
Article
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