What is the optimal effect-site concentration of remifentanil for minimizing the cardiovascular changes to endotracheal intubation during induction with propofol in elderly patients? / 대한마취과학회지
Korean Journal of Anesthesiology
; : 392-397, 2009.
Article
in Ko
| WPRIM
| ID: wpr-179772
Responsible library:
WPRO
ABSTRACT
BACKGROUND: The addition of remifentanil during propofol TCI (target controlled infusion) attenuates the hemodynamic changes induced by endotracheal intubation. This study examined the optimal effect-site concentration of remifentanil to minimize the cardiovascular changes to endotracheal intubation in elderly patients. METHODS: Fifty ASA 1 or 2 elderly patients scheduled for elective surgery under general anesthesia were assigned randomly to one of two groups according to the effect-site concentration of remifentanil. Each group was administered 4 microgram/ml of propofol TCI with 1 ng/ml (group R1) or 3 ng/ml (group R3) of remifentanil. The heart rate (HR), systolic (SAP), mean (MAP) and diastolic arterial pressure (DAP) were measured at pre-induction, before and after endotracheal intubation. RESULTS: After intubation, the HR, SAP, MAP and DAP increased significantly in the two groups compared with the pre-intubation values. However, the HR, SAP, MAP and DAP for group R3 were lower than group R1 for 5 min after intubation. CONCLUSIONS: In elderly patients administered 4 microg/ml of propofol TCI, we suggest that the optimal effect-site concentration of remifentanil to minimize the cardiovascular changes to endotracheal intubation is 3 ng/ml rather than 1 ng/ml.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Piperidines
/
Propofol
/
Arterial Pressure
/
Heart Rate
/
Hemodynamics
/
Intubation
/
Intubation, Intratracheal
/
Anesthesia, General
Limits:
Aged
/
Humans
Language:
Ko
Journal:
Korean Journal of Anesthesiology
Year:
2009
Type:
Article