Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
Allergy, Asthma & Immunology Research
;
: 288-295, 2014.
Article
in English
| WPRIM
| ID: wpr-17987
ABSTRACT
Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties predated the cloning of their classical receptors and the development of drugs that modify their synthesis and actions. Recent studies have revealed unanticipated insights into the regulation of cys-LT synthesis, the function of the cys-LTs in innate and adaptive immunity and human disease, and the identification of a new receptor for the cys-LTs. This review highlights these studies and summarizes their potential pathobiologic and therapeutic implications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Arachidonate 5-Lipoxygenase
/
Leukotrienes
/
Clone Cells
/
Arachidonic Acid
/
Inflammation Mediators
/
Cloning, Organism
/
Adaptive Immunity
Limits:
Humans
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2014
Type:
Article
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