A New Rat Model of Cisplatin-induced Neuropathic Pain
The Korean Journal of Pain
;
: 236-243, 2015.
Article
in English
| WPRIM
| ID: wpr-180008
ABSTRACT
BACKGROUND:
Chemotherapy-induced peripheral neuropathy is a major side effect of anti-cancer drugs, and our knowledge of its mechanisms is lacking. Several models for chemotherapy-induced neuropathy have been introduced. However, the outcomes of these models differ significantly among laboratories. Our object was to create a model of chemotherapy-induced neuropathy in rats with cancer.METHODS:
Female Sprague-Dawley rats were used. Mammary rat metastasis tumor (MRMT-1) cells were implanted subcutaneously in rats. Chemotherapy-induced peripheral neuropathy was induced by injection of cisplatin once a day for four days. The responses to mechanical and thermal stimuli were examined using von Frey filaments, acetone, and radiant heat.RESULTS:
Cisplatin (2 mg/kg/day) produced mechanical allodynia, while it did not induce cold allodynia or thermal hyperalgesia. This dose of cisplatin could work successfully against cancer. Body weight loss was not observed in cisplatin-treated rats, nor were other abnormal behaviors noted in the same rats.CONCLUSIONS:
Repeated injection of intraperitoneal cisplatin induced peripheral neuropathic pain in rats. Thus, this type of rat model has broad applicability in studies related to searching for the mechanism of cisplatin-induced mechanical allodynia and agents for the treatment of neuropathic pain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acetone
/
Body Weight
/
Cisplatin
/
Rats, Sprague-Dawley
/
Peripheral Nervous System Diseases
/
Models, Animal
/
Drug Therapy
/
Hot Temperature
/
Hyperalgesia
/
Neoplasm Metastasis
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
The Korean Journal of Pain
Year:
2015
Type:
Article
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