The effect of tulobuterol patches on the respiratory system after endotracheal intubation
Journal of Dental Anesthesia and Pain Medicine
;
: 265-270, 2017.
Article
in English
| WPRIM
| ID: wpr-18004
ABSTRACT
BACKGROUND:
Endotracheal intubation during anesthesia induction may increase airway resistance (R(aw)) and decrease dynamic lung compliance (Cdyn). We hypothesized that prophylactic treatment with a transdermal β2-agonist tulobuterol patch (TP) would help to reduce the risk of bronchospasm after placement of the endotracheal tube.METHODS:
Eighty-two American Society of Anesthesiologists (ASA) category I or II adult patients showing obstructive patterns were divided randomly into a control and a TP group (n = 41 each). The night before surgery, a 2-mg TP was applied to patients in the TP group. Standard monitors were recorded, and target controlled infusion (TCI) with propofol and remifentanil was used for anesthesia induction and maintenance. Simultaneously, end-tidal carbon dioxide, R(aw), and Cdyn were determined at 5, 10, and 15 min intervals after endotracheal intubation.RESULTS:
There was no significant difference in demographic data between the two groups. The TP group was associated with a lower R(aw) and a higher Cdyn, as compared to the control group. R(aw) was significantly lower at 10 min (P < 0.05) and 15 min (P < 0.01), and Cdyn was significantly higher at 5 min (P < 0.05) and 15 min (P < 0.01) in the TP group. A trend towards a lower R(aw) was observed showing a statistically significant difference 5 min after endotracheal intubation (P < 0.01) in each group.CONCLUSIONS:
Prophylactic treatment with TP showed a bronchodilatory effect through suppressing an increase in R(aw) and a decrease in C(dyn) after anesthesia induction without severe adverse effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory System
/
Bronchial Spasm
/
Carbon Dioxide
/
Propofol
/
Airway Resistance
/
Lung Compliance
/
Intubation, Intratracheal
/
Anesthesia
Limits:
Adult
/
Humans
Language:
English
Journal:
Journal of Dental Anesthesia and Pain Medicine
Year:
2017
Type:
Article
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