Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 205-211, 2002.
Article
in Korean
| WPRIM
| ID: wpr-18019
ABSTRACT
PURPOSE:
To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used for the genotyping analyses, and statistical evaluation was performed by an unconditional logistic regression model.RESULTS:
No association was observed in the study subjects, or the premenopausal women group with GSTP1 Val allele. However, postmenopausal women with GSTP1 Val allele had a reduced risk of breast cancer (OR=0.3, 95% CI=0.1~0.7). When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).CONCLUSION:
Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Breast
/
Breast Neoplasms
/
Alcohol Drinking
/
Case-Control Studies
/
Logistic Models
/
Polymerase Chain Reaction
/
Risk Factors
/
Alleles
/
Genotype
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Cancer Research and Treatment
Year:
2002
Type:
Article
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