Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson's Disease
Journal of Movement Disorders
;
: 144-151, 2016.
Article
in English
| WPRIM
| ID: wpr-180367
ABSTRACT
OBJECTIVE:
We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson’s disease (PD).METHODS:
We selected drug-naïve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score ≤ -2.RESULTS:
Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP.CONCLUSION:
This exploratory study showed that baseline cognition in drug-naïve PD patients might be related to the visit-to-visit variability of DBP and/or HR.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Office Visits
/
Parkinson Disease
/
Blood Pressure
/
Follow-Up Studies
/
Cognition
/
Cognitive Dysfunction
/
Seoul
/
Heart
/
Heart Rate
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Movement Disorders
Year:
2016
Type:
Article
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