A Case of Adult T-cell leukemia / lymphoma / 대한피부과학회지
Korean Journal of Dermatology
;
: 295-299, 2002.
Article
in Korean
| WPRIM
| ID: wpr-180468
ABSTRACT
Adult T-cell leukemia/lymphoma (ATLL) is an often aggressive and fatal malignancy of mature CD4+ T lymphocytes, characterized by leukemia, lymphadenopathy, hypercalcemia and lytic bone lesions. Diagnosis of ATLL is based cm abnormal T lymphocytes in the peripheral blood and histologically and cytologically proven lymphoid malignancy with T cell surface antigens. Anti-HTLV-I serum antibodies and demonstration of clonality to HTLV-I proviral DNA are included. We report a case of ATLL in a 64-year-old man who had a painful nodule on the right cheek and multiple scattered papules and nodules on the trunk for 2 months. He had multiple cervical and axillary lymph node enlargements and hepatosplenomegaly. On laboratory finding peripheral leukocytes count was 33,400/mm3 with 63% atypical lymphocytes. Clover-shaped lyrnphocytes with multilobulated nuclei were found in peripheral blood and bone marrow. Histologic findings showed dense bandlike infiltrations of atypical lymphocytes in the dermis with angiocentricity. The surface phenotype of these abnormal cells were CD2+, CD3+, CD4+, CD30+ and HLA-DR+ and HTLV-I specific antibodies were found.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Bone Marrow
/
DNA
/
Lymphocytes
/
T-Lymphocytes
/
Human T-lymphotropic virus 1
/
Leukemia-Lymphoma, Adult T-Cell
/
Leukemia
/
Cheek
/
Dermis
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2002
Type:
Article
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