Your browser doesn't support javascript.
loading
Treatment Outcome and Analysis of the Prognostic Factors of High Grade Glioma Treated by Postoperative Radiotherapy / 대한방사선종양학회지
The Journal of the Korean Society for Therapeutic Radiology and Oncology ; : 117-124, 2010.
Article in Korean | WPRIM | ID: wpr-180482
ABSTRACT

PURPOSE:

To analyze the postoperative radiotherapy results and prognostic factors in patients with WHO grade 3 and 4 gliomas. MATERIALS AND

METHODS:

A total of 99 patients with malignant gliomas who underwent postoperative radiotherapy between 1988 and 2007 were enrolled in this study. Total resections, subtotal resections (> or =50%), partial resections (<50%), and biopsies were performed in 16, 38, 22, and 23 patients, respectively. In total there were 32, 63 and 4 WHO grade 3, 4, and unspecified high grade gliomas, respectively. The biologically equivalent dose was in the range of 18.6 to 83.3 Gy(10) (median dose, 72.2 Gy(10)). We retrospectively analyzed survival rate, patterns of failure, prognostic factors, and adverse effects.

RESULTS:

The median follow-up time was 11 months and there were 54 patients (54.5%) with local failure. The one and 2-year survival rates were 56.6% and 29.3%, respectively, and the median survival duration was 13 months. The one and 2-year progression-free survival rates (PFS) were 31.3% and 18.2%, respectively, and the median PFS was 7 months. The prognostic factors for overall survival were age (p=0.0001), surgical extents (subtotal resection, p=0.023; partial resection, p=0.009; biopsy only, p=0.002), and enhancement of tumor in postoperative imaging study (p=0.049). The factors affecting PFS were age (p=0.036), tumor enhancement of the postoperative imaging study (p=0.006). There were 3 patients with grade 3 and 4 side effects during and after radiotherapy.

CONCLUSION:

In addition to age and surgical extents, tumor enhancement of the postoperative imaging study was included in the prognostic factors. The most common relapse patterns were local failures and hence, additional studies are needed to improve local control rates.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Biopsy / Survival Rate / Retrospective Studies / Follow-Up Studies / Treatment Outcome / Disease-Free Survival / Glioma Type of study: Observational study / Prognostic study Limits: Humans Language: Korean Journal: The Journal of the Korean Society for Therapeutic Radiology and Oncology Year: 2010 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Biopsy / Survival Rate / Retrospective Studies / Follow-Up Studies / Treatment Outcome / Disease-Free Survival / Glioma Type of study: Observational study / Prognostic study Limits: Humans Language: Korean Journal: The Journal of the Korean Society for Therapeutic Radiology and Oncology Year: 2010 Type: Article