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Living Donor Exchange Program for Adult Living Donor Liver Transplantation: Preliminary Experience at the Asan Medical Center, Korea / 대한이식학회지
The Journal of the Korean Society for Transplantation ; : 92-96, 2008.
Article in Korean | WPRIM | ID: wpr-180614
ABSTRACT

PURPOSE:

When performing donor screening for living donor liver transplantation (LDLT) for an adult patient with end- stage liver disease, ABO blood group incompatibility is the most common cause of donor exclusion. To cope with this problem without performing ABO-incompatible LDLT, living donor exchange program has been maintained at the Asan Medical Center, Seoul, Korea since September 2003. Here we introduce the clinical experience of 6 cases of adult LDLT allocated by living donor exchange program.

METHODS:

From February, 1997 to December 2006. 1208 cases of adult LDLT were performed in our institution. Among them, there were 6 cases allocating through donor exchange program to avoid ABO blood group mismatching. Three sets of 2 donor-recipient combination pairs were made after direct one-to-one donor-recipient matching.

RESULTS:

Two sets of donor exchange LDLT were performed on elective surgery basis, but one in emergency situation. Two living donors and 2 recipients underwent LDLT operations at the same time at the same institution. All 6 living donors recovered well. All of the 6 recipients are doing well to date although 1 recipient had undergone prolonged intensive care for surgical complications. There was no emotional or psychological conflict related to donor exchange program.

CONCLUSION:

This is the world-first report on donor exchange adult LDLT. Although this is a preliminary report with only 3 sets, donor exchange program for adult LDLT appears to be a feasible modality to promote LDLT. We believe it can be applicable to a wider population of LDLT after widespread consensus formation.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphatidylethanolamines / Tissue Donors / Blood Group Incompatibility / Liver Transplantation / Living Donors / Critical Care / Consensus / Donor Selection / Emergencies / Korea Type of study: Practice guideline Limits: Adult / Humans Country/Region as subject: Asia Language: Korean Journal: The Journal of the Korean Society for Transplantation Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphatidylethanolamines / Tissue Donors / Blood Group Incompatibility / Liver Transplantation / Living Donors / Critical Care / Consensus / Donor Selection / Emergencies / Korea Type of study: Practice guideline Limits: Adult / Humans Country/Region as subject: Asia Language: Korean Journal: The Journal of the Korean Society for Transplantation Year: 2008 Type: Article