Clinical Manifestations of Mycobacterium Tuberculosis Infection after Renal Transplantation / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 58-65, 2008.
Article
in Korean
| WPRIM
| ID: wpr-180619
ABSTRACT
PURPOSE:
Transplant patients under immunosuppression are susceptible to mycobacterium tuberculosis infection. We analyzed renal transplant recipients, to evaluate the risk factors, clinical characteristics, and long-term outcomes of post- transplant tuberculosis (TB).METHODS:
This study is based on the records of renal allograft recipients from October 1991 to June 2006 in two transplant centers in Korea. The demographic data, clinical manifestations, and long-term outcomes of this cohort of patients were retrospectively analyzed.RESULTS:
Total 617 patients were enrolled in this study. Eighteen cases of TB (2.92%) occurred with a mean interval from transplant to diagnosis of TB of 33.1 (range 1~121) months. Most of post-transplant TB were pulmonary TB (including pleural) (13/18), and extrapulmonary TB occurred in 5/18. There was no difference in the prevalence of diabetes mellitus, hepatitis B or C, and immunosuppressive agents between the patients who had developed post- transplant TB and who had not. However, there was higher incidence of acute rejection in post-transplant TB group (0.9+/-1.1 vs. 0.4+/-0.6, P=0.043), and post-transplant TB group had a tendency toward more past history of TB infection (P=0.096). Thirteen patients were successfully treated, 2 patients have been under treatment and 3 patients died. The patient survival was significantly reduced by post- transplant TB in multivariate analysis (relative risk=3.355, P=0.038).CONCLUSION:
Post-transplant TB is a serious problem, which is associated with poor outcomes in renal transplant patients. Therefore, high index of suspicion is warranted to ensure early diagnosis and prompt initiation of treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Rejection, Psychology
/
Transplantation, Homologous
/
Tuberculosis
/
Incidence
/
Prevalence
/
Multivariate Analysis
/
Retrospective Studies
/
Risk Factors
/
Cohort Studies
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
The Journal of the Korean Society for Transplantation
Year:
2008
Type:
Article
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